Puss in Boots discovers that his passion for adventure has taken its toll: He has burned through eight of his nine lives, leaving him with only one life left. Puss sets out on an epic journey to find the mythical Last Wish and restore his nine lives.
Ashitaka, a prince of the disappearing Emishi people, is cursed by a demonized boar god and must journey to the west to find a cure. Along the way, he encounters San, a young human woman fighting to protect the forest, and Lady Eboshi, who is trying to destroy it. Ashitaka must find a way to bring balance to this conflict.